The genetics of schizophrenia

A. S. Bassett, E. W.C. Chow, Linda Brzustowicz

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The complex genetic nature of schizophrenia poses a great challenge for investigators seeking causative genetic mutations. Nonetheless, multiple independent research programs are converging to identify a relatively small number of chromosome locations that appear to contain schizophrenia susceptibility genes. Sixteen genome-wide searches have revealed 7 chromosomal regions for which there are three or more findings suggestive of linkage. For two of these regions (1q21-q22 and 13q32), the evidence satisfies strict criteria for significant linkage after allowing for a search of the entire genome. A clinically relevant genetic subtype of schizophrenia (22qDS) has been identified.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalNeuroScience News
Volume4
Issue number1
StatePublished - Jan 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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