The complex genetic nature of schizophrenia poses a great challenge for investigators seeking causative genetic mutations. Nonetheless, multiple independent research programs are converging to identify a relatively small number of chromosome locations that appear to contain schizophrenia susceptibility genes. Sixteen genome-wide searches have revealed 7 chromosomal regions for which there are three or more findings suggestive of linkage. For two of these regions (1q21-q22 and 13q32), the evidence satisfies strict criteria for significant linkage after allowing for a search of the entire genome. A clinically relevant genetic subtype of schizophrenia (22qDS) has been identified.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Jan 1 2001|
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