The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

B. M. Musa, N. A. Galadanci, M. Coker, S. Bussell, M. H. Aliyu

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5–27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7–-25.6) and 24.4 % (95 % CI 18.4–30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.

Original languageEnglish (US)
Pages (from-to)1757-1764
Number of pages8
JournalAnnals of Hematology
Volume95
Issue number11
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology

Keywords

  • Africa
  • Meta-analysis
  • Pulmonary hypertension
  • Sickle cell disease
  • Tricuspid velocity

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