The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

B. M. Musa; N. A. Galadanci; M. Coker; S. Bussell; M. H. Aliyu

doi:10.1007/s00277-016-2693-z

The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

B. M. Musa, N. A. Galadanci, M. Coker, S. Bussell, M. H. Aliyu

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5–27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7–-25.6) and 24.4 % (95 % CI 18.4–30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.

Original language	English (US)
Pages (from-to)	1757-1764
Number of pages	8
Journal	Annals of Hematology
Volume	95
Issue number	11
DOIs	https://doi.org/10.1007/s00277-016-2693-z
State	Published - Oct 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology

Keywords

Africa
Meta-analysis
Pulmonary hypertension
Sickle cell disease
Tricuspid velocity

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title = "The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis",

abstract = "Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5–27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7–-25.6) and 24.4 % (95 % CI 18.4–30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.",

keywords = "Africa, Meta-analysis, Pulmonary hypertension, Sickle cell disease, Tricuspid velocity",

author = "Musa, {B. M.} and Galadanci, {N. A.} and M. Coker and S. Bussell and Aliyu, {M. H.}",

note = "Funding Information: This study is not supported by any grant. Publisher Copyright: {\textcopyright} 2016, Springer-Verlag Berlin Heidelberg.",

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T1 - The global burden of pulmonary hypertension in sickle cell disease

T2 - a systematic review and meta-analysis

AU - Musa, B. M.

AU - Galadanci, N. A.

AU - Coker, M.

AU - Bussell, S.

AU - Aliyu, M. H.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5–27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7–-25.6) and 24.4 % (95 % CI 18.4–30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.

AB - Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5–27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7–-25.6) and 24.4 % (95 % CI 18.4–30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.

KW - Africa

KW - Meta-analysis

KW - Pulmonary hypertension

KW - Sickle cell disease

KW - Tricuspid velocity

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ER -

The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis

Abstract

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