The golgi-cox method

Gitanjali Das, Kenneth Reuhl, Renping Zhou

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Scopus citations


One of the best neurohistologic methods to reveal the cytoarchitecture of the brain and detailed morphology of neurons with unsurpassed clarity has been the Golgi staining. It is based on the principle of metallic impregnation of neurons, allowing visualization in their entirety including cell soma, axons, dendrites, and spines. In this chapter, we describe the Golgi-Cox protocol standardized in our laboratory that can be used to study experimental effects of different genetic manipulations on spatial distribution of neurons, dendrite density, spine number and morphology to elucidate gene functions during development and in adult brain.

Original languageEnglish (US)
Title of host publicationNeural Development
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Number of pages9
ISBN (Print)9781627034432
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics


  • Axon
  • Camillo Golgi
  • Cox
  • Dendrite
  • Golgi staining
  • Light microscope
  • Neuron
  • Spine


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