The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

Jean Pierre Etchegaray, Lei Zhong, Catherine Li, Telmo Henriques, Eileen Ablondi, Tomoyoshi Nakadai, Capucine Van Rechem, Christina Ferrer, Kenneth N. Ross, Jee Eun Choi, Ann Samarakkody, Fei Ji, Andrew Chang, Ruslan I. Sadreyev, Sridhar Ramaswamy, Sergei Nechaev, Johnathan R. Whetstine, Robert G. Roeder, Karen Adelman, Alon GorenRaul Mostoslavsky

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Historically, histone deacetylases have been described as inhibitors of transcription initiation by compacting chromatin at the transcriptional starting site. Etchegaray et al. identified the histone deacetylase SIRT6 as a critical modulator of transcriptional pausing and elongation, acting downstream of recruitment of Pol II.

Original languageEnglish (US)
Pages (from-to)683-699.e7
JournalMolecular cell
Volume75
Issue number4
DOIs
StatePublished - Aug 22 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • BRD4
  • BRD4
  • NELF
  • SIRT6
  • chromatin
  • epigenetics
  • histone deacetylation
  • transcription elongation
  • transcriptional pausing

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