The HLA-A, -B, and -DR phenotypes and tuberculosis

C. H. Hwang, S. Khan, N. Ende, B. T. Mangura, L. B. Reichman, J. Chou

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The HLA-A, -B, and -DR antigens were studied in black Americans to analyze deviation in phenotype distribution between ATS Class 3 patients with tuberculosis disease and ATS Class 2 healthy persons with significant tuberculin reaction, but no tuberculosis. Statistical analyses with Fisher's exact test revealed a significant difference in frequency distribution of HLA-B5 (p = 0.046), HLA-DR5 (p = 0.0276), and HLA-DR6y (p = 0.0095) between ATS Class 2 and ATS Class 3 patients. There was a significant decrease in HLA-DR6y (p = 0.01) but increase in HLA-B5 and HLA-DR5 phenotypes in ATS Class 3 patients.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalAmerican Review of Respiratory Disease
Issue number2
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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