The host response in graft versus host disease. I. Radiosensitive T cells of host origin inhibit parental anti-F1 cytotoxicity in murine chronic graft versus host disease

Ajay B. Singh, Kris Hiehle, Manjeet Singh, Amanda E. Jetzt, Sean M. O’Connell, Richard A. Mann

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Murine graft versus host (GVH) disease takes two forms depending on the parental/F1 strain combination employed. Acute lethal GVH disese is characterized by anemia, lymphopenia, hypogammaglobulinemia, profound anti-F1 cytotoxicity, and the loss of cytotoxic potential against third-party alloantigen. In contrast to this, chronic GVH disease is characterized by polyclonal B cell activation, auto-antibody production, no anti-F1 cytotoxicity, and retained cytotoxicity against allotargets. We now report that this marked disparity in disease expression results from a radio-sensitive host mechanism which protects the F1 mouse from parental anti-F1 cytotoxicity in mice undergoing chronic GVH disease. Cellular analysis revealed that protection in chronic GVH disease is mediated by a phenotypically complex system of genetically unrestricted radiosensitive T cells of F1 origin. These cells fail to functionally emerge in mice undergoing acute lethal GVH disease.

Original languageEnglish (US)
Pages (from-to)24-38
Number of pages15
JournalCellular Immunology
Volume151
Issue number1
DOIs
StatePublished - Oct 1 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology

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