The immune response to parasitic helminths: Insights from murine models

William Gause, Joseph F. Urban, Miguel J. Stadecker

Research output: Contribution to journalReview article

176 Citations (Scopus)

Abstract

Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant experimental murine models, representing the spectrum of human diseases, have been helpful in analyzing and characterizing the host immune response to the different helminths. Although this response is largely defined by type-2 immunity, recent observations have identified important differences regarding the development and function of T helper and other effector cells that can mediate immunopathology and protection in response to infection with these important pathogens.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalTrends in Immunology
Volume24
Issue number5
DOIs
StatePublished - May 1 2003
Externally publishedYes

Fingerprint

Helminths
Immunity
Parasites
Theoretical Models
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Gause, William ; Urban, Joseph F. ; Stadecker, Miguel J. / The immune response to parasitic helminths : Insights from murine models. In: Trends in Immunology. 2003 ; Vol. 24, No. 5. pp. 269-277.
@article{226e16e193f34f24a122739aac12b604,
title = "The immune response to parasitic helminths: Insights from murine models",
abstract = "Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant experimental murine models, representing the spectrum of human diseases, have been helpful in analyzing and characterizing the host immune response to the different helminths. Although this response is largely defined by type-2 immunity, recent observations have identified important differences regarding the development and function of T helper and other effector cells that can mediate immunopathology and protection in response to infection with these important pathogens.",
author = "William Gause and Urban, {Joseph F.} and Stadecker, {Miguel J.}",
year = "2003",
month = "5",
day = "1",
doi = "10.1016/S1471-4906(03)00101-7",
language = "English (US)",
volume = "24",
pages = "269--277",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "5",

}

The immune response to parasitic helminths : Insights from murine models. / Gause, William; Urban, Joseph F.; Stadecker, Miguel J.

In: Trends in Immunology, Vol. 24, No. 5, 01.05.2003, p. 269-277.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The immune response to parasitic helminths

T2 - Insights from murine models

AU - Gause, William

AU - Urban, Joseph F.

AU - Stadecker, Miguel J.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant experimental murine models, representing the spectrum of human diseases, have been helpful in analyzing and characterizing the host immune response to the different helminths. Although this response is largely defined by type-2 immunity, recent observations have identified important differences regarding the development and function of T helper and other effector cells that can mediate immunopathology and protection in response to infection with these important pathogens.

AB - Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant experimental murine models, representing the spectrum of human diseases, have been helpful in analyzing and characterizing the host immune response to the different helminths. Although this response is largely defined by type-2 immunity, recent observations have identified important differences regarding the development and function of T helper and other effector cells that can mediate immunopathology and protection in response to infection with these important pathogens.

UR - http://www.scopus.com/inward/record.url?scp=0038739290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038739290&partnerID=8YFLogxK

U2 - 10.1016/S1471-4906(03)00101-7

DO - 10.1016/S1471-4906(03)00101-7

M3 - Review article

C2 - 12738422

AN - SCOPUS:0038739290

VL - 24

SP - 269

EP - 277

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 5

ER -