TY - JOUR
T1 - The immune response to parasitic helminths
T2 - Insights from murine models
AU - Gause, William C.
AU - Urban, Joseph F.
AU - Stadecker, Miguel J.
N1 - Funding Information:
This work was supported by NIH grants RO1 AI31678 and RO1 AI47478 to W.C.G., and RO1 AI18919 and RO1 AI48736 to M.J.S. We thank Fred Finkelman (University of Cincinnati School of Medicine, Cincinnati, OH, USA) and Dr. Kathryn Else (University of Manchester, Manchester, UK) for reviewing the manuscript. We also thank our colleagues and collaborators who contributed to the work described in this review.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant experimental murine models, representing the spectrum of human diseases, have been helpful in analyzing and characterizing the host immune response to the different helminths. Although this response is largely defined by type-2 immunity, recent observations have identified important differences regarding the development and function of T helper and other effector cells that can mediate immunopathology and protection in response to infection with these important pathogens.
AB - Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant experimental murine models, representing the spectrum of human diseases, have been helpful in analyzing and characterizing the host immune response to the different helminths. Although this response is largely defined by type-2 immunity, recent observations have identified important differences regarding the development and function of T helper and other effector cells that can mediate immunopathology and protection in response to infection with these important pathogens.
UR - https://www.scopus.com/pages/publications/0038739290
UR - https://www.scopus.com/pages/publications/0038739290#tab=citedBy
U2 - 10.1016/S1471-4906(03)00101-7
DO - 10.1016/S1471-4906(03)00101-7
M3 - Review article
C2 - 12738422
AN - SCOPUS:0038739290
SN - 1471-4906
VL - 24
SP - 269
EP - 277
JO - Trends in Immunology
JF - Trends in Immunology
IS - 5
ER -