The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 t cell response in children

Hans M.L. Spiegel, Rohit Chandwani, Megan E. Sheehy, Joanna Dobroszycki, Glenn Fennelly, Andrew Wiznia, Jayme Radding, Mona Rigaud, Henry Pollack, William Borkowsky, Michael Rosenberg, Douglas F. Nixon

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

This cross-sectional study investigated the effect of early highly active antiretroviral therapy (HAART) on human immunodeficiency virus (HTV) type 1-specific CD8 T cell responses in children. HIV-1-specific CD8 T cell responses were quantified using an enzyme-linked immunospot assay to measure interferon-γ-secreting cells. HIV-1-infected children were classifted by time of HAART initiation prior to age 1 year or after age 2 years as early (n = 24) or late (n = 28) treated. The magnitude and breadth of the HIV-1- specific CD8 T cell response was significantly lower in children receiving early compared with late HAART treatment (P = .0007 and .0001, respectively). However, total CD8 T cell responses in the early HAART treatment group did not differ significantly from those of age-matched non-HAART-treated controls (n = 30). Thus, the reduced magnitude and breadth of the HIV-1-specific CD8 T cell response in early HAART-treated children is due to their younger age.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalJournal of Infectious Diseases
Volume182
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 t cell response in children'. Together they form a unique fingerprint.

Cite this