The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer

Lara Hathout, Terence Williams, Salma K. Jabbour

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Purpose of Review: Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radiation therapy (IMRT), proton therapy (PT), stereotactic body radiation therapy (SBRT), and brachytherapy (BT) has been increasing over the past 10 years. This review will highlight the advantages and drawbacks of these techniques. Recent Findings: IMRT, PT, SBRT, and BT achieve a higher target coverage conformity and a higher organ at risk sparing and enable dose escalation compared to 3DCRT. Some studies suggest a reduction in gastrointestinal and hematologic toxicities and an increase in the complete pathologic response rate; however, the clinical benefit of these techniques remains controversial. Summary: The results of these new techniques seem encouraging despite conclusive data. Further trials are required to establish their role in rectal cancer.

Original languageEnglish (US)
Pages (from-to)61-72
Number of pages12
JournalCurrent Colorectal Cancer Reports
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2017

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Rectal Neoplasms
Radiotherapy
Radiation
Proton Therapy
Brachytherapy
Organs at Risk
Therapeutics
Technology

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Oncology
  • Gastroenterology

Keywords

  • IMRT
  • Novel technologies
  • Proton therapy
  • Rectal cancer
  • SBRT

Cite this

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abstract = "Purpose of Review: Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radiation therapy (IMRT), proton therapy (PT), stereotactic body radiation therapy (SBRT), and brachytherapy (BT) has been increasing over the past 10 years. This review will highlight the advantages and drawbacks of these techniques. Recent Findings: IMRT, PT, SBRT, and BT achieve a higher target coverage conformity and a higher organ at risk sparing and enable dose escalation compared to 3DCRT. Some studies suggest a reduction in gastrointestinal and hematologic toxicities and an increase in the complete pathologic response rate; however, the clinical benefit of these techniques remains controversial. Summary: The results of these new techniques seem encouraging despite conclusive data. Further trials are required to establish their role in rectal cancer.",
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The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer. / Hathout, Lara; Williams, Terence; Jabbour, Salma K.

In: Current Colorectal Cancer Reports, Vol. 13, No. 1, 01.02.2017, p. 61-72.

Research output: Contribution to journalReview article

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AU - Williams, Terence

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N2 - Purpose of Review: Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radiation therapy (IMRT), proton therapy (PT), stereotactic body radiation therapy (SBRT), and brachytherapy (BT) has been increasing over the past 10 years. This review will highlight the advantages and drawbacks of these techniques. Recent Findings: IMRT, PT, SBRT, and BT achieve a higher target coverage conformity and a higher organ at risk sparing and enable dose escalation compared to 3DCRT. Some studies suggest a reduction in gastrointestinal and hematologic toxicities and an increase in the complete pathologic response rate; however, the clinical benefit of these techniques remains controversial. Summary: The results of these new techniques seem encouraging despite conclusive data. Further trials are required to establish their role in rectal cancer.

AB - Purpose of Review: Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radiation therapy (IMRT), proton therapy (PT), stereotactic body radiation therapy (SBRT), and brachytherapy (BT) has been increasing over the past 10 years. This review will highlight the advantages and drawbacks of these techniques. Recent Findings: IMRT, PT, SBRT, and BT achieve a higher target coverage conformity and a higher organ at risk sparing and enable dose escalation compared to 3DCRT. Some studies suggest a reduction in gastrointestinal and hematologic toxicities and an increase in the complete pathologic response rate; however, the clinical benefit of these techniques remains controversial. Summary: The results of these new techniques seem encouraging despite conclusive data. Further trials are required to establish their role in rectal cancer.

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