The incidence of ectopic/heterotopic pregnancies after blastocyst-stage frozen-thawed embryo transfers compared with that after cleavage-stage: a Society for Assisted Reproductive Technologies Clinical Outcomes Reporting System study

Kavitha Krishnamoorthy, Patricia Greenberg, Barry E. Perlman, Sara S. Morelli, Sangita K. Jindal, Peter G. McGovern

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To investigate whether there is a difference in the ectopic/heterotopic pregnancy rate of blastocyst-stage frozen-thawed embryo transfers (FETs) compared with that of cleavage-stage FETs. Design: A retrospective cohort study. Setting: Not applicable. Patient(s): Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619), as reported to the Society for Assisted Reproductive Technology from 2004 to 2013. Intervention(s): None. Main Outcome Measure(s): Pregnancy outcomes, specifically ectopic pregnancy rates and heterotopic pregnancy rates. Result(s): Among those who became pregnant, there was a significantly lower incidence of ectopic/heterotopic pregnancies in blastocyst-stage FETs versus that in cleavage-stage FETs (0.8% vs. 1.1%). The differences in ectopic/heterotopic pregnancy rates remained statistically significant after controlling for confounders such as tubal factor infertility and number of embryos transferred. Conclusion(s): Blastocyst-stage FET was associated with a lower ectopic/heterotopic pregnancy rate compared with cleavage-stage FET.

Original languageEnglish (US)
Pages (from-to)421-427
Number of pages7
JournalF and S Reports
Volume2
Issue number4
DOIs
StatePublished - Dec 2021

All Science Journal Classification (ASJC) codes

  • Embryology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Keywords

  • Ectopic pregnancy
  • blastocyst-stage FET
  • cleavage-stage FET
  • heterotopic pregnancy

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