The infant microbiome development: Mom matters

Noel T. Mueller, Elizabeth Bakacs, Joan Combellick, Zoya Grigoryan, Maria G. Dominguez-Bello

Research output: Contribution to journalReview articlepeer-review

530 Scopus citations

Abstract

The infant microbiome plays an essential role in human health and its assembly is determined by maternal-offspring exchanges of microbiota. This process is affected by several practices, including Cesarean section (C-section), perinatal antibiotics, and formula feeding, that have been linked to increased risks of metabolic and immune diseases. Here we review recent knowledge about the impacts on infant microbiome assembly, discuss preventive and restorative strategies to ameliorate the effects of these impacts, and highlight where research is needed to advance this field and improve the health of future generations.

Original languageEnglish (US)
Pages (from-to)109-117
Number of pages9
JournalTrends in Molecular Medicine
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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