The Influence of Rheumatoid Arthritis Disease Characteristics on Heart Failure

Elena Myasoedova, Cynthia S. Crowson, Paulo J. Nicola, Hilal Maradit-Kremers, John M. Davis, Véronique L. Roger, Terry M. Therneau, Sherine E. Gabriel

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Objective. To examine the influence of rheumatoid arthritis (RA) characteristics and antirheumatic medications on the risk of heart failure (HF) in patients with RA. Methods. A population-based incidence cohort of RA patients aged ≥ 18 years (1987 American College of Rheumatology criteria first met between January 1, 1980, and January 1, 2008) with no history of HF was followed until onset of HF (defined by Framingham criteria), death, or January 1, 2008. We collected data on RA characteristics, antirheumatic medications, and cardiovascular (CV) risk factors. Cox models adjusting for age, sex, and calendar year were used to analyze the data. Results. The study included 795 RA patients [mean age 55.3 yrs, 69% women, 66% rheumatoid factor (RF)-positive]. During the mean followup of 9.7 years, 92 patients developed HF. The risk of HF was associated with RF positivity (HR 1.6, 95% CI 1.0, 2.5), erythrocyte sedimentation rate (ESR) at RA incidence (HR 1.6, 95% CI 1.2, 2.0), repeatedly high ESR (HR 2.1, 95% CI 1.2, 3.5), severe extra - articular manifestations (HR 3.1, 95% CI 1.9, 5.1), and corticosteroid use (HR 2.0, 95% CI 1.3, 3.2), adjusting for CV risk factors and coronary heart disease (CHD). Methotrexate users were half as likely to have HF as nonusers (HR 0.5, 95% CI 0.3, 0.9). Conclusion. Several RA characteristics and the use of corticosteroids were associated with HF, with adjustment for CV risk factors and CHD. Methotrexate use appeared to be protective against HF. These findings suggest an independent effect of RA on HF that may be further modified by antirheumatic treatment. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)1601-1606
Number of pages6
JournalJournal of Rheumatology
Issue number8
StatePublished - Aug 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology


  • Determinants
  • Heart failure
  • Rheumatoid arthritis


Dive into the research topics of 'The Influence of Rheumatoid Arthritis Disease Characteristics on Heart Failure'. Together they form a unique fingerprint.

Cite this