The longevity gender gap: are telomeres the explanation?

Abraham Aviv, Jerry Shay, Karre Christensen, Woodring Wright

Research output: Contribution to journalReview article

47 Scopus citations


In this Perspective, we focus on the greater longevity of women as compared with men. We propose that, like aging itself, the longevity gender gap is exceedingly complex and argue that it may arise from sex-related hormonal differences and from somatic cell selection that favors cells more resistant to the ravages of time. We discuss the interplay of these factors with telomere biology and oxidative stress and suggest that an explanation for the longevity gender gap may arise from a better understanding of the differences in telomere dynamics between men and women.

Original languageEnglish (US)
JournalScience of aging knowledge environment : SAGE KE
Issue number23
StatePublished - Jan 1 2005


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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