The mammalian brain rsec6/8 complex

Shu Chan Hsu, Anthony E. Ting, Christopher D. Hazuka, Svend Davanger, James W. Kenny, Yun Kee, Richard H. Scheller

Research output: Contribution to journalArticlepeer-review

211 Scopus citations

Abstract

rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.

Original languageEnglish (US)
Pages (from-to)1209-1219
Number of pages11
JournalNeuron
Volume17
Issue number6
DOIs
StatePublished - Dec 1996

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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