The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry

Susan L. Ackerman, Audrey G. Minden, Cho Yau Yeung

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The murine adenosine deaminase gene has a structurally archetypal TATAA-box-deficient G+C-rich promoter. The three Sp1 binding sites of the promoter are neither necessary nor sufficient for promoter function. Minimal basal promoter activity resides within a 48-bp element downstream of the Sp1 binding sites. This element shows an imperfect dyad symmetry around the promoter's major transcriptional initiation site and contains at least two nuclear protein binding sites. The distinctive sequence characteristics and nuclear protein binding locations of this element led us to propose a model for how such promoters may function.

Original languageEnglish (US)
Pages (from-to)11865-11869
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number24
DOIs
StatePublished - Dec 15 1993

All Science Journal Classification (ASJC) codes

  • General

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