The nature and biology of basement membranes

Ambra Pozzi, Peter D. Yurchenco, Renato V. Iozzo

Research output: Contribution to journalReview articlepeer-review

165 Scopus citations

Abstract

Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices that often act as linings or partitions in organisms. Previously considered as passive scaffolds segregating polarized cells, such as epithelial or endothelial cells, from the underlying mesenchyme, basement membranes have now reached the center stage of biology. They play a multitude of roles from blood filtration to muscle homeostasis, from storing growth factors and cytokines to controlling angiogenesis and tumor growth, from maintaining skin integrity and neuromuscular structure to affecting adipogenesis and fibrosis. Here, we will address developmental, structural and biochemical aspects of basement membranes and discuss some of the pathogenetic mechanisms causing diseases linked to abnormal basement membranes.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalMatrix Biology
Volume57-58
DOIs
StatePublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Keywords

  • Collagen
  • Discoidin domain receptor
  • Heparan sulfate proteoglycan
  • Integrin
  • Laminin

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