The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory

M. Jin, X. M. Wang, Y. Tu, X. H. Zhang, X. Gao, N. Guo, Z. Xie, G. Zhao, N. Jing, B. M. Li, L. Yu

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Tob (transducer of ErbB2) is a negative cell cycle regulator with anti-proliferative activity in the periphery. Using a behavioral screening paradigm to look for novel gene functions in the brain, we identified Tob as a brain-expressed protein involved in learning and memory. Behavioral training of fear-conditioning triggered a transient elevation of Tob protein, which preceded the formation of long-term memory. Functional perturbation of Tob by intra-CA1 infusion of antisense oligonucleotides in rats impaired spatial learning and memory in the Morris water maze and long-term memory for contextual fear conditioning, two behavioral paradigms that require the hippocampus. Furthermore, long-term potentiation was suppressed by Tob antisense infusion into the CA1 region. Together, these results indicate that the negative cell cycle regulator Tob is a multifunctional protein involved in hippocampus-dependent learning and memory.

Original languageEnglish (US)
Pages (from-to)647-659
Number of pages13
JournalNeuroscience
Volume131
Issue number3
DOIs
StatePublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Antisense oligonucleotide
  • LTP
  • Negative cell cycle regulator

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