The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning

Xin Ming Wang, Xiang Gao, Xue Han Zhang, Yan Yang Tu, Mei Lei Jin, Guo Ping Zhao, Lei Yu, Nai He Jing, Bao Ming Li

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Tob (transducer of ErbB-2) is a negative cell cycle regulator with anti-proliferative activity in peripheral tissues. Our previous study identified Tob as a protein involved in hippocampus-dependent memory consolidation (M.L. Jin, X.M. Wang, Y.Y. Tu, X.H. Zhang, X. Gao, N. Guo, Z.Q. Xie, G.P. Zhao, N.H. Jing, B.M. Li, Y.Yu, The negative cell cycle regulator, Tob (Transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory, Neuroscience 131 (2005) 647-659). Here, we provide evidence that Tob in the central nervous system is engaged in acquisition of motor skill. Tob has a relatively high expression in the cerebellum. Tob expression is up-regulated in the cerebellum after rats receive training on a rotarod-running task. Rats infused with Tob antisense oligonucleotides into the 4th ventricle exhibit a severe deficit in running on a rotating rod or walking across a horizontally elevated beam.

Original languageEnglish (US)
Pages (from-to)1023-1027
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume340
Issue number4
DOIs
StatePublished - Feb 24 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Keywords

  • Cerebellum
  • Motor skill learning
  • Rat
  • Tob

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