TY - JOUR
T1 - The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells
AU - Studzinski, George P.
AU - Harrison, Jonathan S.
N1 - Funding Information:
We thank Dr Li-Huei Tsai, Harvard Medical School, for generously providing p35Nck5a knock-out mice, and Dr George Parker, Biotechnics, Inc., for performing necropsies and tissue preparations. The support of the USA PHS, National Cancer Institute, by grant RO1-CA 44722 is also gratefully acknowledged.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Cyclin-dependent kinase 5 (Cdk5) and its activator p35Nck5a are an odd but interesting couple. Recent work has established that in spite of their names, Cdk5 is clearly not cyclin-dependent, while p35Nck5a is not exclusively neuronal. Indeed, p35Nck5a and/or Cdk5 activity has been demonstrated to be present in human and rat promyelocytic cell lines, and in normal human monocytes. Further, monocytes from mice in which p35Nck5a gene was deleted do not express non-specific esterase, an enzyme present in normal monocytes, while transfection of Cdk5 together with p35Nck5a into myeloblastic cells leads to the expression of this marker of the monocytic phenotype. Thus, the Cdk5/p35Nck5a complex appears to play an important role in monocytic differentiation.
AB - Cyclin-dependent kinase 5 (Cdk5) and its activator p35Nck5a are an odd but interesting couple. Recent work has established that in spite of their names, Cdk5 is clearly not cyclin-dependent, while p35Nck5a is not exclusively neuronal. Indeed, p35Nck5a and/or Cdk5 activity has been demonstrated to be present in human and rat promyelocytic cell lines, and in normal human monocytes. Further, monocytes from mice in which p35Nck5a gene was deleted do not express non-specific esterase, an enzyme present in normal monocytes, while transfection of Cdk5 together with p35Nck5a into myeloblastic cells leads to the expression of this marker of the monocytic phenotype. Thus, the Cdk5/p35Nck5a complex appears to play an important role in monocytic differentiation.
KW - Cdk activator
KW - Cyclin-dependent kinase 5 (Cdk5)
KW - HL60 cells
KW - Monocyte
KW - p35
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U2 - 10.1080/1042819021000030009
DO - 10.1080/1042819021000030009
M3 - Review article
C2 - 12688339
AN - SCOPUS:0037299465
SN - 1042-8194
VL - 44
SP - 235
EP - 240
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 2
ER -