Monoamine neurons possess presynaptic autoreceptors, sensitive to the neuron's own neurotransmitter, which modulate the calcium-dependent, stimulus-evoked release of transmitter from the nerve endings. Agonists reduce, whereas antagonists enhance evoked release. What are the mechanisms underlying autoreceptor-mediated effects at monoamine nerve terminals, and does this phenomenon play a physiological role in vivo? In the following review James Tepper, Philip Groves and Stephen Young summarize recent biochemical and electrophysiological findings on the autoinhibition of monoamine release in the mammalian CNS.
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