The neuropharmacology of the autoinhibition of monoamine release

James M. Tepper, Philip M. Groves, Stephen J. Young

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Monoamine neurons possess presynaptic autoreceptors, sensitive to the neuron's own neurotransmitter, which modulate the calcium-dependent, stimulus-evoked release of transmitter from the nerve endings. Agonists reduce, whereas antagonists enhance evoked release. What are the mechanisms underlying autoreceptor-mediated effects at monoamine nerve terminals, and does this phenomenon play a physiological role in vivo? In the following review James Tepper, Philip Groves and Stephen Young summarize recent biochemical and electrophysiological findings on the autoinhibition of monoamine release in the mammalian CNS.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalTrends in Pharmacological Sciences
Issue numberC
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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