The neurophenomenology of early psychosis: An integrative empirical study

B. Nelson, S. Lavoie, Gawęda, E. Li, L. A. Sass, D. Koren, P. D. McGorry, B. N. Jack, J. Parnas, A. Polari, K. Allott, J. A. Hartmann, T. J. Whitford

Research output: Contribution to journalArticle

Abstract

Background: The integration of various domains or levels of analysis (clinical, neurobiological, genetic, etc.) has been a challenge in schizophrenia research. A promising approach is to use the core phenomenological features of the disorder as an organising principle for other levels of analysis. Minimal self-disturbance (fragility in implicit first-person perspective, presence and agency) is emerging as a strong candidate to play this role. This approach was adopted in a previously described theoretical neurophenomenological model that proposed that source monitoring deficits and aberrant salience may be neurocognitive/neurobiological processes that correlate with minimal self-disturbance on the phenomenological level, together playing an aetiological role in the onset of schizophrenia spectrum disorders. The current paper presents full cross-sectional data from the first empirical test of this model. Methods: Fifty ultra-high risk for psychosis patients, 39 first episode psychosis patients and 34 healthy controls were assessed with a variety of clinical measures, including the Examination of Anomalous Self-Experience (EASE), and neurocognitive and neurophysiological (EEG) measures of source monitoring deficits and aberrant salience. Results: Linear regression indicated that source monitoring (composite score across neurocognitive and neurophysiological measures), with study group as an interaction term, explained 39.8% of the variance in EASE scores (R2 = 0.41, F(3,85) = 14.78, p < 0.001), whereas aberrant salience (composite score) explained only 6% of the variance in EASE scores (R2 = 0.06, F(3,85) = 1.44, p = 0.93). Aberrant salience measures were more strongly related to general psychopathology measures, particularly to positive psychotic symptoms, than to EASE scores. Discussion: A neurophenomenological model of minimal self-disturbance in schizophrenia spectrum disorders may need to be expanded from source monitoring deficits to encompass other relevant constructs such as temporal processing, intermodal/multisensory integration, and hierarchical predictive processing. The cross-sectional data reported here will be expanded with longitudinal analysis in subsequent reports. These data and other related recent research show an emerging picture of neuro-features of core phenomenological aspects of schizophrenia spectrum disorders beyond surface-level psychotic symptoms.

Original languageEnglish (US)
Article number102845
JournalConsciousness and cognition
Volume77
DOIs
StatePublished - Jan 2020

Fingerprint

Psychotic Disorders
Schizophrenia
Psychopathology
Research
Electroencephalography
Linear Models
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology

Keywords

  • Neurocognition
  • Neurophysiology
  • Phenomenology
  • Prodrome
  • Psychosis
  • Schizophrenia

Cite this

Nelson, B. ; Lavoie, S. ; Gawęda ; Li, E. ; Sass, L. A. ; Koren, D. ; McGorry, P. D. ; Jack, B. N. ; Parnas, J. ; Polari, A. ; Allott, K. ; Hartmann, J. A. ; Whitford, T. J. / The neurophenomenology of early psychosis : An integrative empirical study. In: Consciousness and cognition. 2020 ; Vol. 77.
@article{f0d89325d29e42b79e6a4dd1ad5fb918,
title = "The neurophenomenology of early psychosis: An integrative empirical study",
abstract = "Background: The integration of various domains or levels of analysis (clinical, neurobiological, genetic, etc.) has been a challenge in schizophrenia research. A promising approach is to use the core phenomenological features of the disorder as an organising principle for other levels of analysis. Minimal self-disturbance (fragility in implicit first-person perspective, presence and agency) is emerging as a strong candidate to play this role. This approach was adopted in a previously described theoretical neurophenomenological model that proposed that source monitoring deficits and aberrant salience may be neurocognitive/neurobiological processes that correlate with minimal self-disturbance on the phenomenological level, together playing an aetiological role in the onset of schizophrenia spectrum disorders. The current paper presents full cross-sectional data from the first empirical test of this model. Methods: Fifty ultra-high risk for psychosis patients, 39 first episode psychosis patients and 34 healthy controls were assessed with a variety of clinical measures, including the Examination of Anomalous Self-Experience (EASE), and neurocognitive and neurophysiological (EEG) measures of source monitoring deficits and aberrant salience. Results: Linear regression indicated that source monitoring (composite score across neurocognitive and neurophysiological measures), with study group as an interaction term, explained 39.8{\%} of the variance in EASE scores (R2 = 0.41, F(3,85) = 14.78, p < 0.001), whereas aberrant salience (composite score) explained only 6{\%} of the variance in EASE scores (R2 = 0.06, F(3,85) = 1.44, p = 0.93). Aberrant salience measures were more strongly related to general psychopathology measures, particularly to positive psychotic symptoms, than to EASE scores. Discussion: A neurophenomenological model of minimal self-disturbance in schizophrenia spectrum disorders may need to be expanded from source monitoring deficits to encompass other relevant constructs such as temporal processing, intermodal/multisensory integration, and hierarchical predictive processing. The cross-sectional data reported here will be expanded with longitudinal analysis in subsequent reports. These data and other related recent research show an emerging picture of neuro-features of core phenomenological aspects of schizophrenia spectrum disorders beyond surface-level psychotic symptoms.",
keywords = "Neurocognition, Neurophysiology, Phenomenology, Prodrome, Psychosis, Schizophrenia",
author = "B. Nelson and S. Lavoie and Gawęda and E. Li and Sass, {L. A.} and D. Koren and McGorry, {P. D.} and Jack, {B. N.} and J. Parnas and A. Polari and K. Allott and Hartmann, {J. A.} and Whitford, {T. J.}",
year = "2020",
month = "1",
doi = "10.1016/j.concog.2019.102845",
language = "English (US)",
volume = "77",
journal = "Consciousness and Cognition",
issn = "1053-8100",
publisher = "Academic Press Inc.",

}

Nelson, B, Lavoie, S, Gawęda, Li, E, Sass, LA, Koren, D, McGorry, PD, Jack, BN, Parnas, J, Polari, A, Allott, K, Hartmann, JA & Whitford, TJ 2020, 'The neurophenomenology of early psychosis: An integrative empirical study', Consciousness and cognition, vol. 77, 102845. https://doi.org/10.1016/j.concog.2019.102845

The neurophenomenology of early psychosis : An integrative empirical study. / Nelson, B.; Lavoie, S.; Gawęda; Li, E.; Sass, L. A.; Koren, D.; McGorry, P. D.; Jack, B. N.; Parnas, J.; Polari, A.; Allott, K.; Hartmann, J. A.; Whitford, T. J.

In: Consciousness and cognition, Vol. 77, 102845, 01.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The neurophenomenology of early psychosis

T2 - An integrative empirical study

AU - Nelson, B.

AU - Lavoie, S.

AU - Gawęda,

AU - Li, E.

AU - Sass, L. A.

AU - Koren, D.

AU - McGorry, P. D.

AU - Jack, B. N.

AU - Parnas, J.

AU - Polari, A.

AU - Allott, K.

AU - Hartmann, J. A.

AU - Whitford, T. J.

PY - 2020/1

Y1 - 2020/1

N2 - Background: The integration of various domains or levels of analysis (clinical, neurobiological, genetic, etc.) has been a challenge in schizophrenia research. A promising approach is to use the core phenomenological features of the disorder as an organising principle for other levels of analysis. Minimal self-disturbance (fragility in implicit first-person perspective, presence and agency) is emerging as a strong candidate to play this role. This approach was adopted in a previously described theoretical neurophenomenological model that proposed that source monitoring deficits and aberrant salience may be neurocognitive/neurobiological processes that correlate with minimal self-disturbance on the phenomenological level, together playing an aetiological role in the onset of schizophrenia spectrum disorders. The current paper presents full cross-sectional data from the first empirical test of this model. Methods: Fifty ultra-high risk for psychosis patients, 39 first episode psychosis patients and 34 healthy controls were assessed with a variety of clinical measures, including the Examination of Anomalous Self-Experience (EASE), and neurocognitive and neurophysiological (EEG) measures of source monitoring deficits and aberrant salience. Results: Linear regression indicated that source monitoring (composite score across neurocognitive and neurophysiological measures), with study group as an interaction term, explained 39.8% of the variance in EASE scores (R2 = 0.41, F(3,85) = 14.78, p < 0.001), whereas aberrant salience (composite score) explained only 6% of the variance in EASE scores (R2 = 0.06, F(3,85) = 1.44, p = 0.93). Aberrant salience measures were more strongly related to general psychopathology measures, particularly to positive psychotic symptoms, than to EASE scores. Discussion: A neurophenomenological model of minimal self-disturbance in schizophrenia spectrum disorders may need to be expanded from source monitoring deficits to encompass other relevant constructs such as temporal processing, intermodal/multisensory integration, and hierarchical predictive processing. The cross-sectional data reported here will be expanded with longitudinal analysis in subsequent reports. These data and other related recent research show an emerging picture of neuro-features of core phenomenological aspects of schizophrenia spectrum disorders beyond surface-level psychotic symptoms.

AB - Background: The integration of various domains or levels of analysis (clinical, neurobiological, genetic, etc.) has been a challenge in schizophrenia research. A promising approach is to use the core phenomenological features of the disorder as an organising principle for other levels of analysis. Minimal self-disturbance (fragility in implicit first-person perspective, presence and agency) is emerging as a strong candidate to play this role. This approach was adopted in a previously described theoretical neurophenomenological model that proposed that source monitoring deficits and aberrant salience may be neurocognitive/neurobiological processes that correlate with minimal self-disturbance on the phenomenological level, together playing an aetiological role in the onset of schizophrenia spectrum disorders. The current paper presents full cross-sectional data from the first empirical test of this model. Methods: Fifty ultra-high risk for psychosis patients, 39 first episode psychosis patients and 34 healthy controls were assessed with a variety of clinical measures, including the Examination of Anomalous Self-Experience (EASE), and neurocognitive and neurophysiological (EEG) measures of source monitoring deficits and aberrant salience. Results: Linear regression indicated that source monitoring (composite score across neurocognitive and neurophysiological measures), with study group as an interaction term, explained 39.8% of the variance in EASE scores (R2 = 0.41, F(3,85) = 14.78, p < 0.001), whereas aberrant salience (composite score) explained only 6% of the variance in EASE scores (R2 = 0.06, F(3,85) = 1.44, p = 0.93). Aberrant salience measures were more strongly related to general psychopathology measures, particularly to positive psychotic symptoms, than to EASE scores. Discussion: A neurophenomenological model of minimal self-disturbance in schizophrenia spectrum disorders may need to be expanded from source monitoring deficits to encompass other relevant constructs such as temporal processing, intermodal/multisensory integration, and hierarchical predictive processing. The cross-sectional data reported here will be expanded with longitudinal analysis in subsequent reports. These data and other related recent research show an emerging picture of neuro-features of core phenomenological aspects of schizophrenia spectrum disorders beyond surface-level psychotic symptoms.

KW - Neurocognition

KW - Neurophysiology

KW - Phenomenology

KW - Prodrome

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85074161807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074161807&partnerID=8YFLogxK

U2 - 10.1016/j.concog.2019.102845

DO - 10.1016/j.concog.2019.102845

M3 - Article

C2 - 31678780

AN - SCOPUS:85074161807

VL - 77

JO - Consciousness and Cognition

JF - Consciousness and Cognition

SN - 1053-8100

M1 - 102845

ER -