The Pathology of Acute Liver Failure

Billie Fyfe, Francisco Zaldana, Chen Liu

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Varied injuries may manifest clinically as acute liver failure. The pathologic features include variable amounts of necrosis and regeneration. This article reviews pathologic classification of patterns of necrosis and associated inflammatory and regenerative responses in specimens from patients with acute liver failure. Detailed pathologic examination of these specimens with clinical pathologic correlation can give the multidisciplinary team vital information regarding etiology and timing as well as extent of injury, and regenerative response. Pathologists are a vital component of the health care team for patients with acute liver failure.

Original languageEnglish (US)
Pages (from-to)257-268
Number of pages12
JournalClinics in Liver Disease
Volume22
Issue number2
DOIs
StatePublished - May 1 2018

Fingerprint

Acute Liver Failure
Pathology
Necrosis
Patient Care Team
Wounds and Injuries
Regeneration

All Science Journal Classification (ASJC) codes

  • Hepatology

Keywords

  • Acetaminophen
  • Acute liver failure pathology
  • Autoimmune hepatitis
  • Hepatotropic viral hepatitis
  • Massive hepatic necrosis
  • Submassive hepatic necrosis
  • Zonal necrosis

Cite this

Fyfe, Billie ; Zaldana, Francisco ; Liu, Chen. / The Pathology of Acute Liver Failure. In: Clinics in Liver Disease. 2018 ; Vol. 22, No. 2. pp. 257-268.
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The Pathology of Acute Liver Failure. / Fyfe, Billie; Zaldana, Francisco; Liu, Chen.

In: Clinics in Liver Disease, Vol. 22, No. 2, 01.05.2018, p. 257-268.

Research output: Contribution to journalReview article

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AU - Zaldana, Francisco

AU - Liu, Chen

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AB - Varied injuries may manifest clinically as acute liver failure. The pathologic features include variable amounts of necrosis and regeneration. This article reviews pathologic classification of patterns of necrosis and associated inflammatory and regenerative responses in specimens from patients with acute liver failure. Detailed pathologic examination of these specimens with clinical pathologic correlation can give the multidisciplinary team vital information regarding etiology and timing as well as extent of injury, and regenerative response. Pathologists are a vital component of the health care team for patients with acute liver failure.

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KW - Autoimmune hepatitis

KW - Hepatotropic viral hepatitis

KW - Massive hepatic necrosis

KW - Submassive hepatic necrosis

KW - Zonal necrosis

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