Survivors of myocardial infarction with <2 PVC/h on 24-h ambulatory electrocardiography were followed up for an average of 25 months (11 to 40 months) while receiving a placebo (1,222 patients) or propranolol, 180 or 240 mg/day (1,234 patients). Three quarters of the participants with PVCs had an average of <2 PVC/h. Only 16 percent did not have any ventricular ectopic activity during the 24 h. Analysis of total mortality according to the number of premature ventricular complexes per hour showed that patients who had PVCs with a very low frequency (<0.5/h) had 49 percent higher mortality than patients who did not have any PVC. Patients who had >0.5 PVC/h but <1 PVC/h had a statistically significant higher mortality rate, 11.7 vs 4.1 percent (p<0.0001) than patients who had no PVC. These data indicate that low ventricular ectopic activity frequency is associated with increased mortality in survivors of acute myocardial infarction.
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine
- Cardiology and Cardiovascular Medicine