TY - JOUR
T1 - The quest for digital health
T2 - From diseases to patients
AU - Androulakis, Ioannis P.
N1 - Funding Information:
The author acknowledges support from NIH MG024211 and GM131800.
Publisher Copyright:
© 2019
PY - 2019/8/4
Y1 - 2019/8/4
N2 - The shift towards non-communicable, chronic, diseases has placed emphasis on understanding the dominant role our everyday activities and broader environment as a major determinant of health. The realization that genetics is but one of the drivers of maintaining health and developing chronic diseases, necessitates that we refocus our attention on the patient and the interactions between life style and environment and the biology and physiology underlying health and chronic diseases. In that respect, we begin to better appreciate that health and disease are fundamentally systems properties and need to be treated as such. In this review, we attempt to first, define the “patient” eco-system, its boundaries and its components and then discuss how to establish and assess the multitude of interactions across the system components. We particularly focus on three environmental and life-style factors: mistimed rest/activity patterns, mistimed feeding patterns and chronic stress.
AB - The shift towards non-communicable, chronic, diseases has placed emphasis on understanding the dominant role our everyday activities and broader environment as a major determinant of health. The realization that genetics is but one of the drivers of maintaining health and developing chronic diseases, necessitates that we refocus our attention on the patient and the interactions between life style and environment and the biology and physiology underlying health and chronic diseases. In that respect, we begin to better appreciate that health and disease are fundamentally systems properties and need to be treated as such. In this review, we attempt to first, define the “patient” eco-system, its boundaries and its components and then discuss how to establish and assess the multitude of interactions across the system components. We particularly focus on three environmental and life-style factors: mistimed rest/activity patterns, mistimed feeding patterns and chronic stress.
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U2 - 10.1016/j.compchemeng.2019.05.030
DO - 10.1016/j.compchemeng.2019.05.030
M3 - Article
AN - SCOPUS:85066253784
SN - 0098-1354
VL - 127
SP - 247
EP - 253
JO - Computers and Chemical Engineering
JF - Computers and Chemical Engineering
ER -