The relationship between obstructive sleep apnea and ruptured intracranial aneurysms

Oleg Y. Chernyshev, Shyamal C. Bir, Tanmoy K. Maiti, Devi Prasad Patra, Hai Sun, Bharat Guthikonda, Roger E. Kelley, Hugo Cuellar, Alireza Minagar, Anil Nanda

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Study Objectives: The role of obstructive sleep apnea (OSA) in the overall outcome of ruptured intracranial aneurysms (RIAs) is unknown. We have investigated the role of OSA in overall outcome of RIAs. Methods: Data from 159 consecutive patients were retrospectively reviewed. A chi-square test and regression analysis were performed to determine the significant difference. A value of P < .05 was considered significant. Results: The prevalence of OSA in RIAs was fivefold higher in the nonaneurysm patient group, P = .002. The number of patients with hypertension (P < .0001), body mass index ≥ 30 (P < .0001), hyperlipidemia (P = .018), chronic heart disease (P = .002) or prior ischemic stroke (P = .001) was significantly higher in the OSA group. Similarly, the number of wide-neck aneurysms (P < .0001) and aneurysm > 7 mm (P = .004), poor Hunt and Hess grade IV-V (P = .005), vasospasms, (P = .03), and patients with poor Modified Rankin Scale scores (3-6) was significantly higher in the OSA group (P < .0001). Interestingly, for the first time in univariate (P = .01) and multivariate (P = .003) regression analysis, OSA was identified as an individual predictor of unfavorable outcome of RIAs. In addition, hypertension (P = .04), smoking (P = .049), chronic heart disease (P = .01), and Hunt and Hess grade IV-V (P = .04) were revealed as predictors of poor outcome of RIAs. Conclusions: This is a novel study to determine the association between OSA and ruptured cerebral aneurysm in terms of comorbidities, size of aneurysm, severity of symptoms, and outcomes after treatment. In addition, for the first time, OSA is identified as a positive predictor of unfavorable outcome of RIAs.

Original languageEnglish (US)
Pages (from-to)1839-1848
Number of pages10
JournalJournal of Clinical Sleep Medicine
Volume15
Issue number12
DOIs
StatePublished - Dec 15 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Keywords

  • Cerebral aneurysms
  • OSA
  • Outcomes
  • Predictors

Fingerprint

Dive into the research topics of 'The relationship between obstructive sleep apnea and ruptured intracranial aneurysms'. Together they form a unique fingerprint.

Cite this