The relationship of prostaglandins to cAMP, IgG, IgM and α-2-macroglobulin in gingival crevicular fluid in chronic adult periodontitis

S. Sengupta, J. Fine, C. Y. Wu-Wang, J. Gordon, V. L.N. Murty, A. Slomiany, B. L. Slomiany

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Gingival crevicular fluid, collected from 8 patients with chronic adult periodontitis before and 21 days after root planing and scaling, was analysed for prostaglandin E2, 6KPGF, cAMP, IgG, IgM and α-2-macroglobulin, and their inter-relationship evaluated. There was a significant decrease in the levels of prostaglandin E2, IgG, IgM and α-2-macroglobulin after treatment, whereas the levels of 6KPGF and cAMP remained essentially unchanged. The level of prostaglandin E2 decreased by 35%, IgG by 32%, IgM by 90%, and α-2-macroglobulin by 79%. There was a significant degree of correlation between prostaglandin E2 and 6KPGF and cAMP before treatment but not after, but no correlation between prostaglandin E2 and IgG, IgM and α-2-macroglobulin either before or after. This correlation pattern indicates the involvement of E2, prostaglandin 6KPGFand cAMP in inflammation in the periodontium. The changes in IgG, IgM and α-2-macroglobulin reflect yet another mechanism of host response which appears to be independent of prostaglandins.

Original languageEnglish (US)
Pages (from-to)593-596
Number of pages4
JournalArchives of Oral Biology
Volume35
Issue number8
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Keywords

  • biochemical profiles
  • gingival crevicular fluid
  • periodontitis

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