The retron: a bacterial retroelement required for the synthesis of msDNA

Sumiko Inouye; Masayori Inouye

doi:10.1016/S0959-437X(05)80088-7

The retron: a bacterial retroelement required for the synthesis of msDNA

Sumiko Inouye, Masayori Inouye

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

'Retrons' are bacterial retroelements responsible for the synthesis of msDNA, a hybrid nucleic acid consisting of a single-stranded DNA that is branched out from an internal guanosine of an RNA molecule via a 2′,5′-phosphodiester linkage. Retrons are found in a minor population of various bacterial species and are extensively diverse. Two important questions now demanding attention are whether retrons are mobile elements and why are they so diverse?

Original language	English (US)
Pages (from-to)	713-718
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	3
Issue number	5
DOIs	https://doi.org/10.1016/S0959-437X(05)80088-7
State	Published - Oct 1993

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

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10.1016/S0959-437X(05)80088-7

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title = "The retron: a bacterial retroelement required for the synthesis of msDNA",

abstract = "'Retrons' are bacterial retroelements responsible for the synthesis of msDNA, a hybrid nucleic acid consisting of a single-stranded DNA that is branched out from an internal guanosine of an RNA molecule via a 2′,5′-phosphodiester linkage. Retrons are found in a minor population of various bacterial species and are extensively diverse. Two important questions now demanding attention are whether retrons are mobile elements and why are they so diverse?",

author = "Sumiko Inouye and Masayori Inouye",

note = "Funding Information: We thank Drs Juan M Garcia-Lobo and T Shimamoto and Mr W Hanlon for the critical reading of this manuscript. The work was supported by a grant from the National Institute of Health (GM44012).",

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AU - Inouye, Masayori

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PY - 1993/10

Y1 - 1993/10

N2 - 'Retrons' are bacterial retroelements responsible for the synthesis of msDNA, a hybrid nucleic acid consisting of a single-stranded DNA that is branched out from an internal guanosine of an RNA molecule via a 2′,5′-phosphodiester linkage. Retrons are found in a minor population of various bacterial species and are extensively diverse. Two important questions now demanding attention are whether retrons are mobile elements and why are they so diverse?

AB - 'Retrons' are bacterial retroelements responsible for the synthesis of msDNA, a hybrid nucleic acid consisting of a single-stranded DNA that is branched out from an internal guanosine of an RNA molecule via a 2′,5′-phosphodiester linkage. Retrons are found in a minor population of various bacterial species and are extensively diverse. Two important questions now demanding attention are whether retrons are mobile elements and why are they so diverse?

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The retron: a bacterial retroelement required for the synthesis of msDNA

Abstract

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