The role of default network deactivation in cognition and disease

Alan Anticevic, Michael W. Cole, John D. Murray, Philip R. Corlett, Xiao Jing Wang, John H. Krystal

Research output: Contribution to journalReview articlepeer-review

491 Scopus citations


A considerable body of evidence has accumulated over recent years on the functions of the default-mode network (DMN) - a set of brain regions whose activity is high when the mind is not engaged in specific behavioral tasks and low during focused attention on the external environment. In this review, we focus on DMN suppression and its functional role in health and disease, summarizing evidence that spans several disciplines, including cognitive neuroscience, pharmacological neuroimaging, clinical neuroscience, and theoretical neuroscience. Collectively, this research highlights the functional relevance of DMN suppression for goal-directed cognition, possibly by reducing goal-irrelevant functions supported by the DMN (e.g., mind-wandering), and illustrates the functional significance of DMN suppression deficits in severe mental illness.

Original languageEnglish (US)
Pages (from-to)584-592
Number of pages9
JournalTrends in Cognitive Sciences
Issue number12
StatePublished - Dec 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


  • Cognition
  • Computational modeling
  • Default-mode network
  • Schizophrenia
  • Suppression


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