The role of laminin in embryonic cell polarization and tissue organization

Shaohua Li, David Edgar, Reinhard Fässler, William Wadsworth, Peter D. Yurchenco

Research output: Contribution to journalReview article

209 Scopus citations


Genetic analyses have revealed that members of the laminin glycoprotein family are required for basement membrane assembly and cell polarization, with subsequent effects on cell survival and tissue organization during metazoan embryogenesis. These functions depend upon the cooperation between laminin polymerization and cell anchorage mediated via interactions with β1-integrins, dystroglycan, and other cell surface receptors.

Original languageEnglish (US)
Pages (from-to)613-624
Number of pages12
JournalDevelopmental Cell
Issue number5
StatePublished - May 1 2003

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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