The role of laminin in embryonic cell polarization and tissue organization

Shaohua Li, David Edgar, Reinhard Fässler, William Wadsworth, Peter D. Yurchenco

Research output: Contribution to journalReview article

204 Citations (Scopus)

Abstract

Genetic analyses have revealed that members of the laminin glycoprotein family are required for basement membrane assembly and cell polarization, with subsequent effects on cell survival and tissue organization during metazoan embryogenesis. These functions depend upon the cooperation between laminin polymerization and cell anchorage mediated via interactions with β1-integrins, dystroglycan, and other cell surface receptors.

Original languageEnglish (US)
Pages (from-to)613-624
Number of pages12
JournalDevelopmental Cell
Volume4
Issue number5
DOIs
StatePublished - May 1 2003

Fingerprint

Laminin
Dystroglycans
Polarization
Tissue
Cell Surface Receptors
Basement Membrane
Integrins
Polymerization
Embryonic Development
Cell Survival
Glycoproteins
Cells

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

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The role of laminin in embryonic cell polarization and tissue organization. / Li, Shaohua; Edgar, David; Fässler, Reinhard; Wadsworth, William; Yurchenco, Peter D.

In: Developmental Cell, Vol. 4, No. 5, 01.05.2003, p. 613-624.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The role of laminin in embryonic cell polarization and tissue organization

AU - Li, Shaohua

AU - Edgar, David

AU - Fässler, Reinhard

AU - Wadsworth, William

AU - Yurchenco, Peter D.

PY - 2003/5/1

Y1 - 2003/5/1

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AB - Genetic analyses have revealed that members of the laminin glycoprotein family are required for basement membrane assembly and cell polarization, with subsequent effects on cell survival and tissue organization during metazoan embryogenesis. These functions depend upon the cooperation between laminin polymerization and cell anchorage mediated via interactions with β1-integrins, dystroglycan, and other cell surface receptors.

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M3 - Review article

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JO - Developmental Cell

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SN - 1534-5807

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