The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)

for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study

Research output: Contribution to journalArticle

Abstract

Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.

Original languageEnglish (US)
Pages (from-to)2109-2120
Number of pages12
JournalAIDS and behavior
Volume23
Issue number8
DOIs
StatePublished - Aug 15 2019

Fingerprint

HIV
Logistic Models
Proxy
Viral Load

All Science Journal Classification (ASJC) codes

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Keywords

  • ARV adherence
  • Appointment adherence
  • Pediatric HIV
  • Pharmacy refill
  • Self-report

Cite this

for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study. / The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV). In: AIDS and behavior. 2019 ; Vol. 23, No. 8. pp. 2109-2120.
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title = "The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)",
abstract = "Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4{\%} (≥ 25{\%}). Among 159 PHIV youth, 79{\%} were adherent by 7-day recall, and 62, 55, and 48{\%} by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95{\%} CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95{\%} CI 1.22, 8.65). Similar associations were observed with higher CD4{\%}. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.",
keywords = "ARV adherence, Appointment adherence, Pediatric HIV, Pharmacy refill, Self-report",
author = "{for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study} and Cenk Yildirim and Garvie, {Patricia A.} and Miriam Chernoff and Wilkins, {Megan L.} and Patton, {E. Doyle} and Williams, {Paige L.} and Nichols, {Sharon L.} and Ram Yogev and Sanders, {Margaret Ann} and Kathleen Malee and Scott Hunter and William Shearer and Mary Paul and Norma Cooper and Lynnette Harris and Murli Purswani and Mahboobullah Baig and Anna Cintron and Ana Navarro and Patricia Garvie and James Blood and Sandra Burchett and Nancy Karthas and Betsy Kammerer and Andrew Wiznia and Marlene Burey and Molly Nozyce and Arry Dieudonne and Linda Bettica and Susan Adubato and Janet Chen and Bulkley, {Maria Garcia} and Latreaca Ivey and Mitzie Grant and Katherine Knapp and Kim Allison and Megan Wilkins and Midnela Acevedo-Flores and Heida Rios and Vivian Olivera and Margarita Silio and Medea Jones and Patricia Sirois and Stephen Spector and Kim Norris and Sharon Nichols and Elizabeth McFarland and Alisa Katai and Jennifer Dunn and Suzanne Paul",
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The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV). / for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study.

In: AIDS and behavior, Vol. 23, No. 8, 15.08.2019, p. 2109-2120.

Research output: Contribution to journalArticle

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T1 - The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)

AU - for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study

AU - Yildirim, Cenk

AU - Garvie, Patricia A.

AU - Chernoff, Miriam

AU - Wilkins, Megan L.

AU - Patton, E. Doyle

AU - Williams, Paige L.

AU - Nichols, Sharon L.

AU - Yogev, Ram

AU - Sanders, Margaret Ann

AU - Malee, Kathleen

AU - Hunter, Scott

AU - Shearer, William

AU - Paul, Mary

AU - Cooper, Norma

AU - Harris, Lynnette

AU - Purswani, Murli

AU - Baig, Mahboobullah

AU - Cintron, Anna

AU - Navarro, Ana

AU - Garvie, Patricia

AU - Blood, James

AU - Burchett, Sandra

AU - Karthas, Nancy

AU - Kammerer, Betsy

AU - Wiznia, Andrew

AU - Burey, Marlene

AU - Nozyce, Molly

AU - Dieudonne, Arry

AU - Bettica, Linda

AU - Adubato, Susan

AU - Chen, Janet

AU - Bulkley, Maria Garcia

AU - Ivey, Latreaca

AU - Grant, Mitzie

AU - Knapp, Katherine

AU - Allison, Kim

AU - Wilkins, Megan

AU - Acevedo-Flores, Midnela

AU - Rios, Heida

AU - Olivera, Vivian

AU - Silio, Margarita

AU - Jones, Medea

AU - Sirois, Patricia

AU - Spector, Stephen

AU - Norris, Kim

AU - Nichols, Sharon

AU - McFarland, Elizabeth

AU - Katai, Alisa

AU - Dunn, Jennifer

AU - Paul, Suzanne

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N2 - Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.

AB - Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.

KW - ARV adherence

KW - Appointment adherence

KW - Pediatric HIV

KW - Pharmacy refill

KW - Self-report

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