The role of STAT1 in viral sensitization to LPS

Joan Durbin, Leslie Doughty, Ken Nguyen, Michael Caligiuri, Jeff Van Deusen, Christine Biron

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The phenomenon of endotoxin sensitization by virus infection is well documented but not yet well understood. Infection by virtually any viral agent will quickly induce expression of type I interferons (IFN-α/β), and type II IFN-γ production will follow as NK cells and T cells are activated. It has been well established that type II IFN pretreatment can intensify the effects of endotoxin. We have recently demonstrated that type I IFN induction by lymphocytic choriomeningitis virus (LCMV) infection dramatically increases TNF-α production following LPS treatment, and that this sensitization by type I IFN is STAT1 dependent. Taken together these data suggest that the STAT1-mediated, MyD88-independent, arm of the LPS signaling pathway plays an important role in endotoxin toxicity, and that this pathway mediates a major component of virus-enhanced LPS sensitization.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalJournal of Endotoxin Research
Volume9
Issue number5
DOIs
StatePublished - 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Toxicology

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