The Role of Store-operated Calcium Channels in Pain

Frances Munoz, Huijuan Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations


Store-operated calcium channels (SOCCs) are calcium-selective cation channels. Recently, there has been explosive growth in establishing the molecular mechanisms that mediate store-operated Ca2+ entry (SOCE) and the role of this process in normal cellular function and disease states. SOCCs and its components appear to play an important role in many Ca2+-dependent processes in nonexcitable cells and are implicated in several possible disorders including allergies, multiple sclerosis, cancer, and inflammatory bowel disease. Recent studies have shown that SOCCs are expressed in the central nervous system (CNS) and involved in neuronal functions and pathological conditions, including chronic pain. In this chapter, we discuss SOCE and its physiological and pathological roles in the CNS. More specifically, we discuss the expression and function of SOCCs and their downstream signaling mechanisms under chronic pain conditions.

Original languageEnglish (US)
Title of host publicationPharmacological Mechanisms and the Modulation of Pain, 2016
EditorsJames E. Barrett
PublisherAcademic Press Inc.
Number of pages13
ISBN (Print)9780128038833
StatePublished - 2016
Externally publishedYes

Publication series

NameAdvances in Pharmacology
ISSN (Print)1054-3589
ISSN (Electronic)1557-8925

All Science Journal Classification (ASJC) codes

  • Pharmacology


  • Cytokine
  • Dorsal root ganglia
  • Inflammation
  • Neuron
  • Pain
  • Spinal cord
  • Store-operated calcium channels
  • YM-58483


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