The role of the pedunculopontine tegmental nucleus in motor disorders

Nadine K. Gut, Philip Winn

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

In this chapter, we discuss why the pedunculopontine is an appropriate target in studying movement disorders, explaining its association with both the pathology and treatment of Parkinsonism. We discuss how various laboratories, including our own, have approached experimental examination of the pedunculopontine and some of the findings that have emerged. These lead us finally to reflect on the nature of movement disorders and how they necessarily involve not just the control of musculature but additionally the complex cognitive processes of decision making - the processes that underlie not just "doing" but also "choosing" and how these are embedded deeper in brain than is often appreciated.

Original languageEnglish (US)
Title of host publicationAnimal Models of Movement Disorders
Subtitle of host publicationVolume II
EditorsEmma Lane, Stephen Dunnett
Pages321-342
Number of pages22
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameNeuromethods
Volume62
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Pharmacology, Toxicology and Pharmaceutics
  • Psychiatry and Mental health

Keywords

  • Action selections
  • Basal ganglia
  • Decision making
  • Deep brain stimulation
  • Mesencephalic locomotor region
  • Parkinsonism

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