The Saccharomyces cerevisiae DNA Repair Gene RAD2 Is Regulated in Meiosis but Not during the Mitotic Cell Cycle

Kiran Madura; Satya Prakash

doi:10.1128/MCB.10.6.3256

The Saccharomyces cerevisiae DNA Repair Gene RAD2 Is Regulated in Meiosis but Not during the Mitotic Cell Cycle

Kiran Madura, Satya Prakash

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The expression of the RAD2 gene of Saccharomyces cerevisiae is elevated upon DNA damage. Here, we show that KAD2 transcript levels also rise approximately eightfold during meiosis but remain constant during the mitotic cell cycle. The period of maximal RAD2 mRNA accumulation during meiosis is consistent with a possible role of KAD2 in a late stage of recombination, in mismatch repair of heteroduplexes, or both.

Original language	English (US)
Pages (from-to)	3256-3257
Number of pages	2
Journal	Molecular and cellular biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1128/MCB.10.6.3256
State	Published - Jun 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1128/MCB.10.6.3256

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title = "The Saccharomyces cerevisiae DNA Repair Gene RAD2 Is Regulated in Meiosis but Not during the Mitotic Cell Cycle",

abstract = "The expression of the RAD2 gene of Saccharomyces cerevisiae is elevated upon DNA damage. Here, we show that KAD2 transcript levels also rise approximately eightfold during meiosis but remain constant during the mitotic cell cycle. The period of maximal RAD2 mRNA accumulation during meiosis is consistent with a possible role of KAD2 in a late stage of recombination, in mismatch repair of heteroduplexes, or both.",

author = "Kiran Madura and Satya Prakash",

year = "1990",

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doi = "10.1128/MCB.10.6.3256",

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publisher = "American Society for Microbiology",

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AU - Madura, Kiran

AU - Prakash, Satya

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N2 - The expression of the RAD2 gene of Saccharomyces cerevisiae is elevated upon DNA damage. Here, we show that KAD2 transcript levels also rise approximately eightfold during meiosis but remain constant during the mitotic cell cycle. The period of maximal RAD2 mRNA accumulation during meiosis is consistent with a possible role of KAD2 in a late stage of recombination, in mismatch repair of heteroduplexes, or both.

AB - The expression of the RAD2 gene of Saccharomyces cerevisiae is elevated upon DNA damage. Here, we show that KAD2 transcript levels also rise approximately eightfold during meiosis but remain constant during the mitotic cell cycle. The period of maximal RAD2 mRNA accumulation during meiosis is consistent with a possible role of KAD2 in a late stage of recombination, in mismatch repair of heteroduplexes, or both.

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JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

IS - 6

ER -

The Saccharomyces cerevisiae DNA Repair Gene RAD2 Is Regulated in Meiosis but Not during the Mitotic Cell Cycle

Abstract

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