The SL autoantibody-antigen system: clinical and biochemical studies

R. M. Bernstein, S. H. Morgan, C. C. Bunn, R. C. Gainey, G. R. Hughes, M. B. Mathews

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A recently described autoantibody, SL, was found from 27 patients with autoimmune disease, including 20 with systemic lupus erythematosus (SLE) where the frequency was 7%. Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL antibody apart from a higher frequency of non-infective fever. Most SL positive sera contained other precipitins, notably antibodies to Ro(SS-A) and the proliferating cell nuclear antigen, PCNA. Anti-SL IgG recognised a protein of 32,000 daltons without associated RNA. This polypeptide was distinguished from a similarly sized component of the Sm and RNP ribonucleoprotein particles by demonstrating different products of partial proteolysis. Although anti-SL antibody is of limited clinical importance, it occurs with twice the frequency of anti-SM antibody in white patients with SLE. Preliminary studies indicate that SL and the Japanese Ki system are identical.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalAnnals of the rheumatic diseases
Issue number5
StatePublished - 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)


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