@article{d061c047cc91432abfbf5f80b09f9164,
title = "The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection",
abstract = "Natural killer (NK) cells are innate lymphocytes that exhibit many features of adaptive immunity, including clonal proliferation and long-lived memory. Here we demonstrate that the BTB-ZF transcription factor Zbtb32 (also known as ROG, FAZF, TZFP and PLZP) was essential for the proliferative burst and protective capacity of virus-specific NK cells. Signals from proinflammatory cytokines were both necessary and sufficient to induce high expression of Zbtb32 in NK cells. Zbtb32 facilitated NK cell proliferation during infection by antagonizing the anti-proliferative factor Blimp-1 (Prdm1). Our data support a model in which Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection.",
author = "Beaulieu, {Aimee M.} and Zawislak, {Carolyn L.} and Toshinori Nakayama and Sun, {Joseph C.}",
note = "Funding Information: We thank members of the Sun lab for technical support and experimental assistance, members of the Memorial Sloan-Kettering NK club for insightful comments and helpful discussions, A. Rudensky, M. van den Brink, M. Li, L. Lanier (University of California San Francisco), D. Sant{\textquoteright}Angelo (Rutgers University) and L. Denzin (Rutgers University) for sharing antibodies and flow cytometry resources and for providing expertise critical to this study and manuscript, G. Gasteiger, K. Schluns (M.D. Anderson) and U. Koszinowski (Max von Pettenkofer-Institute) for providing many of the parent and recombinant viruses used in our study, S. Way (University of Minnesota) for providing femurs from Il12rb2−/− × Ifnar1−/− mice for use in making bone marrow chimeras, the Immunological Genome Consortium for providing the microarray data used in this study26, and J.P. Houchins and his team at R&D Systems for providing the experimental anti-Zbtb32 flow cytometry antibody used in this study. A.M.B. was supported by US National Institutes of Health T32 award (CA009149). J.C.S. was supported by the Searle Scholars Program, the Cancer Research Institute, and grants from the National Institutes of Health (AI085034 and AI100874).",
year = "2014",
month = jun,
doi = "10.1038/ni.2876",
language = "English (US)",
volume = "15",
pages = "546--553",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "6",
}