The transdermal delivery of zwitterionic drugs II: the flux of zwitterion salts

Gerard C. Mazzenga, Bret Berner, Frank Jordan

Research output: Contribution to journalArticle

22 Scopus citations


By forming the salt of zwitterions, dramatic increases in skin and membrane transport may be achieved. The rules for counterion selection followed the covalency of the salt formed and the solubilities of the salt in both the solvent and the membrane. Practical application to transdermal delivery may often require a more moderate pH than those obtained. The skin permeation data were consistent with a model of porous transport. However, the diffusion constants in epidermis were surprisingly small for porous transport.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalJournal of Controlled Release
Issue number2
StatePublished - Jan 1 1992


All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


  • Membrane transport
  • Salt
  • Skinpermeation
  • Transdermai delivery
  • Zwitterion

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