By forming the salt of zwitterions, dramatic increases in skin and membrane transport may be achieved. The rules for counterion selection followed the covalency of the salt formed and the solubilities of the salt in both the solvent and the membrane. Practical application to transdermal delivery may often require a more moderate pH than those obtained. The skin permeation data were consistent with a model of porous transport. However, the diffusion constants in epidermis were surprisingly small for porous transport.
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Membrane transport
- Transdermai delivery