The United States is facing unprecedented challenges in the field of health and health care: what can and should we do about it? A call to action

The United States is experiencing unprecedented disruptions to its health infrastructure due to recent federal policy changes threatening public health programs, research funding, and healthcare equity. Policy reversals have rescinded critical initiatives, including diversity, equity, and inclusion efforts; Medicaid support; and international health collaborations. Data removal and censorship further hinder public health decision-making, while personnel and budget cuts to the National Institutes of Health and the Centers for Disease Control and Prevention jeopardize research and local health initiatives. These shifts threaten the career development of early career researchers, limit access to crucial datasets, and undermine the stability of public health training programs. The recommended response for researchers, professionals, and concerned citizens is to take immediate action. Advocacy efforts should focus on engaging policymakers, issuing public statements, and lobbying for alternative funding. Public awareness campaigns are needed to counteract misinformation, leverage media influence, and educate communities on the implications of policy rollbacks. Strengthening grassroots networks by supporting local health initiatives, digital outreach, and mobilizing professionals is critical. Protecting scientific integrity requires advocating for data restoration, opposing censorship, and promoting independent research funding. Legal and institutional resistance can help challenge harmful policies through court actions and amicus briefs. International collaboration should be prioritized to sustain global health partnerships despite US government withdrawals. Proactive leadership in safeguarding public health research and practice has never been greater. Through strategic advocacy, legal action, and community engagement, we should defend public health research, ensure essential services access, and uphold health equity for all.