Thermodynamics of transfer of molecules and groups from nonpolar to aqueous environments. I. Method. n-butyric acid at 25°

Kenneth J. Breslauer, Bruce Terrin, Julian M. Sturtevant

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16 Scopus citations

Abstract

A method involving flow microcalorimetry is described for determination of the enthalpy of transfer of acidic or basic molecules from water-immiscible organic solvents to water. In this first paper the method is illustrated by application to the transfer of n-butyric acid from toluene to water at 25°. Distribution experiments were performed to permit evaluation of the free energy of transfer. Detailed consideration was given to the enthalpy and free-energy contributions arising from dimerization of the solute in the organic solvent. The thermodynamic parameters for the process involving monomeric solute n- C3H7COOH (toluene) = n-C3H7COOH (H2O) are ΔG°298 = (-1220 ± 50) cal mol-1, ΔH298 = (-3520 ± 150) cal mol-1, and ΔS°298 = (-7.7 ± 0.5) cal deg-1 mol-1.

Original languageEnglish (US)
Pages (from-to)2363-2366
Number of pages4
JournalJournal of physical chemistry
Volume78
Issue number23
DOIs
StatePublished - 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physical and Theoretical Chemistry

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