Thin film nanoelectronic probe for protein detection

Rahim Esfandyarpour, Mehdi Javanmard, Zahra Koochak, Hesaam Esfandyarpour, James S. Harris, Ronald W. Davis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations


There are many biological macro-molecules such as nucleic acids, lipids, carbohydrates and proteins. While each of them plays a vital (and interesting) part in life but there is something special about the proteins. Proteins are the key link between the processes of information and replication that take place on a genetic level and the infrastructure of living features. Understanding the properties of proteins is the key to understanding the spark of the life. In this paper we describe our study of various electrical properties of protein when performing measurements at the nanoscale. To achieve this goal we designed and fabricated a nanoelectronic probe. This nano structure consists of four thin film layers. There are two conductive layers and an insulative layer in between. There is also a protective oxide layer as the top most layer. This layer is to prevent the exposure of conductive electrodes to the solution. Underneath the bottom electrode, there is another oxide layer, which can be a thermally grown oxide. This layer insulates the first electrode from the substrate. In this study, while we use non-specific detection of streptavidin protein as a proof of concept, we emphasize that the findings of this study can be extended to specific detection of target proteins, where in this case a specific probe molecule would also be immobilized on the sensor surface.

Original languageEnglish (US)
Title of host publicationBioelectronics
Subtitle of host publicationMaterials, Interfaces and Applications
PublisherMaterials Research Society
Number of pages6
ISBN (Print)9781632661531
StatePublished - 2013
Externally publishedYes
Event2013 MRS Spring Meeting - San Francisco, CA, United States
Duration: Apr 1 2013Apr 5 2013

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Other2013 MRS Spring Meeting
Country/TerritoryUnited States
CitySan Francisco, CA

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


  • Biosensors
  • DNA
  • Impedance biosensor
  • Label free
  • Nanotechnology


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