Thioredoxin-binding protein-2 (TBP-2): Its potential roles in the aging process

Toru Yoshida, Norihiko Kondo, Shin Ichi Oka, Md Kaimul Ahsan, Tomijiro Hara, Hiroshi Masutani, Hajime Nakamura, Junji Yodoi

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Thioredoxin (TRX) binding protein-2 (TBP-2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP-2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP-2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP-2 was also reported to be a cellular senescence-associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP-2 genetically modified mice and found that TBP-2 is closely linked to lipid metabolism. Indeed, TBP-2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP-2 in the regulation of energy utilization connected to the aging process.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalBioFactors
Volume27
Issue number1-4
DOIs
StatePublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

Keywords

  • Aging
  • Energy metabolism
  • Lipid
  • Redox
  • Thioredoxin

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