Threading the needle: Getting selenocysteine into proteins

Jesse Donovan; Paul R. Copeland

doi:10.1089/ars.2009.2878

Threading the needle: Getting selenocysteine into proteins

Jesse Donovan, Paul R. Copeland

RWJ-Biochemistry&Molecular Bio

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

The co-translational incorporation of selenocysteine (Sec) requires that UGA be recognized as a sense rather than a nonsense codon. This is accomplished by the concerted action of a Sec insertion sequence (SECIS) element, SECIS binding protein 2, and a ternary complex of the Sec specific elongation factor, Sec-tRNA^Sec, and GTP. The mechanism by which they alter the canonical protein synthesis reaction has been elusive. Here we present an overview of the mechanistic perspective on Sec incorporation, highlighting recent advances in the field.

Original language	English (US)
Pages (from-to)	881-892
Number of pages	12
Journal	Antioxidants and Redox Signaling
Volume	12
Issue number	7
DOIs	https://doi.org/10.1089/ars.2009.2878
State	Published - Apr 1 2010

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Molecular Biology
Clinical Biochemistry
Cell Biology

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10.1089/ars.2009.2878

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Threading the needle: Getting selenocysteine into proteins

Abstract

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