Threading the needle: Getting selenocysteine into proteins

Jesse Donovan, Paul R. Copeland

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


The co-translational incorporation of selenocysteine (Sec) requires that UGA be recognized as a sense rather than a nonsense codon. This is accomplished by the concerted action of a Sec insertion sequence (SECIS) element, SECIS binding protein 2, and a ternary complex of the Sec specific elongation factor, Sec-tRNASec, and GTP. The mechanism by which they alter the canonical protein synthesis reaction has been elusive. Here we present an overview of the mechanistic perspective on Sec incorporation, highlighting recent advances in the field.

Original languageEnglish (US)
Pages (from-to)881-892
Number of pages12
JournalAntioxidants and Redox Signaling
Issue number7
StatePublished - Apr 1 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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