Three time windows for amnestic effect of antibodies to cell adhesion molecule L1 in chicks

Anna Tiunova, Konstantin V. Anokhin, Melitta Camartin, Steven P.R. Rose

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The L1/NgCAM cell adhesion molecule is involved in neurite outgrowth, axonal fasciculation and cell migration in the nervous system. We studied the effects of antibodies against L1 injected intracranially at various times before and after training 2-day-old chicks in a visual categorization task. Memory retention was tested 24 h post-training. Anti-L1 antibodies impaired task retention only when administered in three restricted time windows: immediately before training, at about 5.5 h after training and from 15 to 18 h after training. No amnesia was produced by injections before, between or after these sensitive periods (from -1 to +21 h relative to training). These results indicate that there are multiple post-training periods during which L1 is involved in the formation of long-term memory.

Original languageEnglish (US)
Pages (from-to)1645-1648
Number of pages4
JournalNeuroReport
Volume9
Issue number7
DOIs
StatePublished - May 11 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Amnesia
  • Cell adhesion molecule
  • Chicks
  • L1
  • Learning
  • Memory

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