Three types of neuronal calcium channel with different calcium agonist sensitivity

Martha C. Nowycky, Aaron P. Fox, Richard W. Tsien

Research output: Contribution to journalArticlepeer-review

203 Scopus citations


How many types of calcium channels exist in neurones? This question is fundamental to understanding how calcium entry contributes to diverse neuronal functions such as transmitter release, neurite extension, spike initiation and rhythmic firing1-3. There is considerable evidence for the presence of more than one type of Ca conductance in neurones4-13 and other cells14-18. However, little is known about single-channel properties of diverse neuronal Ca channels, or their responsiveness to dihydropyridines, compounds widely used as labels in Ca channel purification19-21. Here we report evidence for the coexistence of three types of Ca channel in sensory neurones of the chick dorsal root ganglion. In addition to a large conductance channel that contributes long-lasting current at strong depolarizations (L), and a relatively tiny conductance that underlies a transient current activated at weak depolarizations (T), we find a third type of unitary activity (N) that is neither T nor L. N-type Ca channels require strongly negative potentials for complete removal of inactivation (unlike L) and strong depolarizations for activation (unlike T). The dihydropyridine Ca agonist Bay K 8644 strongly increases the opening probability of L-, but not T- or N-type channels.

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
Issue number6027
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'Three types of neuronal calcium channel with different calcium agonist sensitivity'. Together they form a unique fingerprint.

Cite this