In this preliminary report the authors describe the preparation of thromboresistant analogs of vascular tissue. These are fiber-reinforced gels prepared by crosslinking collagen with chondroi-tin 6-sulfate and with hyaluronic acid. Typically, all three macromolecular substances are components of vascular tissue. The former GAG (glycose-aminoglycan) is sulfated while the latter is not; their repeat units are shown as reported by Swann. Standardized in vitro hematological tests were carried out in the laboratories of Dr. E. W. Salzman, Beth Israel Hospital, Boston. In all cases, use was made of freshly drawn human venous blood. Whole blood clotting time (WBCT) was determined by filling tubes fabricated from the test material with whole blood. It is shown that reaction with chondroitin 6-sulfate increases significantly the blood compatibility of collagen, as evidenced by prlongation in WBCT and the near abolition of platelet aggregating activity, both evident when collagen is reacted with this mucopolysaccharide. In addition to their significant thromboresistance, collagen GAG composite gels prepared also possess mechanical properties which make them surgically useful.
|Original language||English (US)|
|Number of pages||6|
|Journal||American Chemical Society, Polymer Preprints, Division of Polymer Chemistry|
|Publication status||Published - Jan 1 1975|
All Science Journal Classification (ASJC) codes
- Polymers and Plastics