Thymalfasin for the treatment of chronic hepatitis C infection

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The purpose of this review article is to examine previous and ongoing studies of thymalfasin in combination with peginterferon-α2a and peginterferon-α2a plus ribavirin in difficult-to-treat hepatitis C virus (HCV) patients. The following studies will be reviewed in detail: (1) Sherman and colleagues conducted a study in 109 HCV RNA positive HVC patients comparing the combination of thymalfasin + IFN versus IFN alone versus placebo. (2) Rustgi et al. evaluated the efficacy and safety of thymalfasin and peg-IFN-α2a in 31 genotype 1, high viral load, HCV nonresponders in a 12-week viral kinetic study. (3) Di Bisceglie, Sherman et al. performed a study of previous HCV nonresponders being retreated with either peginterferon-α2a plus thymalfasin or peginterferon-α2a plus placebo. (4) Poo and colleagues in Mexico evaluated triple combination therapy using thymalfasin, peginterferon-α2a, and ribavirin for the treatment of Hispanic HCV nonresponders.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
PublisherBlackwell Publishing Inc.
Pages357-367
Number of pages11
ISBN (Print)1573317012, 9781573317016
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1112
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Keywords

  • HCV
  • HCV nonresponders
  • Thymalfasin
  • Thymosin alpha 1
  • Zadaxin

Cite this

Rustgi, V. K. (2007). Thymalfasin for the treatment of chronic hepatitis C infection. In Annals of the New York Academy of Sciences (pp. 357-367). (Annals of the New York Academy of Sciences; Vol. 1112). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1415.034