Thymus biopsy in children with acquired immunodeficiency syndrome

V. V. Joshi, J. M. Oleske, S. Saad, C. Gadol, E. Connor, R. Bobila, A. B. Minnefor

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Thymic biopsy was done at the time of open lung biopsy in 11 children with acquired immunodeficiency syndrome (AIDS). Precocious involution, involution mimicking dysplasia designated as dysinvolution, and thymitis characterized by lymphomononuclear or plasmacytic infiltration, medullary lymphoid follicles, or medullary multinucleated giant cells were seen. Thymic biopsy is helpful in distinguishing AIDS from certain congenital immunodeficiency disorders. The three different types of thymic lesions may represent progression and/or different expressions of thymic epithelial injury in children with AIDS.

Original languageEnglish (US)
Pages (from-to)837-842
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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