Thyroid hormone signaling pathways: Time for a more precise nomenclature

Frederic Flamant; Sheue Yann Cheng; Anthony N. Hollenberg; Lars C. Moeller; Jacques Samarut; Fredric E. Wondisford; Paul M. Yen; Samuel Refetoff

doi:10.1210/en.2017-00250

Thyroid hormone signaling pathways: Time for a more precise nomenclature

Frederic Flamant, Sheue Yann Cheng, Anthony N. Hollenberg, Lars C. Moeller, Jacques Samarut, Fredric E. Wondisford, Paul M. Yen, Samuel Refetoff

Robert Wood Johnson Medical School (RWJMS), Medicine

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed.

Original language	English (US)
Pages (from-to)	2052-2057
Number of pages	6
Journal	Endocrinology
Volume	158
Issue number	7
DOIs	https://doi.org/10.1210/en.2017-00250
State	Published - Jul 2017

All Science Journal Classification (ASJC) codes

Endocrinology

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10.1210/en.2017-00250

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abstract = "Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed.",

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AU - Flamant, Frederic

AU - Cheng, Sheue Yann

AU - Hollenberg, Anthony N.

AU - Moeller, Lars C.

AU - Samarut, Jacques

AU - Wondisford, Fredric E.

AU - Yen, Paul M.

AU - Refetoff, Samuel

PY - 2017/7

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AB - Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed.

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Thyroid hormone signaling pathways: Time for a more precise nomenclature

Abstract

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