Thyroid hormone signaling pathways: Time for a more precise nomenclature

Frederic Flamant, Sheue Yann Cheng, Anthony N. Hollenberg, Lars C. Moeller, Jacques Samarut, Fredric E. Wondisford, Paul M. Yen, Samuel Refetoff

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations


Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed.

Original languageEnglish (US)
Pages (from-to)2052-2057
Number of pages6
Issue number7
StatePublished - Jul 2017

All Science Journal Classification (ASJC) codes

  • Endocrinology


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