Tissue concentrations of water-soluble vitamins in normal and diabetic rats.

A. S. Reddi, G. N. Jyothirmayi, B. DeAngelis, O. Frank, H. Baker

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Changes in circulating and tissue concentrations of several vitamins have been reported in diabetic animals and human subjects. In this study, the effect of short-term (2 weeks) streptozotocin diabetes on folate, B6, B12, thiamin, nicotinate, pantothenate, riboflavin and biotin in liver, kidney, pancreas, heart, brain and skeletal muscle of rats was investigated. The tissue distribution of vitamins varied widely in normal rats. Diabetes significantly lowered folate in kidney, heart, brain, and muscle; B6 in brain; B12 in heart; thiamin in liver and heart; nicotinate in liver, kidney, heart and brain; pantothenate in all tissues; riboflavin in liver, kidney, heart, and muscle. These results indicate that experimental diabetes causes a depression of several water-soluble vitamins in various tissues of rats.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalInternational Journal for Vitamin and Nutrition Research
Issue number2
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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